TriacsinCisafungalmetabolitethatactsasacompetitiveinhibitorofacyl-CoAsynthetase,preventingconversionoffattyacidstofattyacyl-CoA.TriacsinCinhibitssynthesisoftriacylglycerol(TAG),diacylglycerol(DAG),cholesterolesters,andphospholipids.TriacsinCincreasesNOsynthesisandeNOSactivity,inducingvasodilatoryactivityandenhancingrelaxationofaorticrings.
| CasNo. | 76896-80-5 |
|---|---|
| Purity | ≥95% |
| Formula | C11H17N3O |
| FormulaWt. | 207.27 |
| IUPACName | N-[(E)-[(2E,4E,7E)-undeca-2,4,7-trienylidene]amino]nitrousamide |
| MeltingPoint | 102-104°C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | T6834MSDSPDF |
|---|---|
| InfoSheet | T6834InfoSheetPDF |
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WeisMT,CrumleyJL,YoungLH,etal.InhibitinglongchainfattyAcylCoAsynthetaseincreasesbasalandagoNIST-stimulatedNOsynthesisinendothelium.CardiovascRes.2004Aug1;63(2):338-46.PMID:15249192.
IgalRA,WangP,ColemanRA.TriacsinCblocksdenovosynthesisofglycerolipidsandcholesterolestersbutnotrecyclingoffattyacidintophospholipid:evidenceforfunctionallyseparatepoolsofacyl-CoA.BiochemJ.1997Jun1;324(Pt2):529-34.PMID:9182714.
