LKT/TUBASTATIN A HYDROCHLORIDE/T8006/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TUBASTATIN A HYDROCHLORIDE/T8006/10 mg

LKT/TUBASTATIN A HYDROCHLORIDE/T8006/10 mg

商品编号： T8006-10mg

品牌： lktlabs

市场价： ¥4080.00

美元价： 2448.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID T8006

Cas No. 1310693-92-5

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tubastatin A is an inhibitor of class IIb histone deacetylases (HDACs), such as HDAC6 and HDAC10. Tubastatin A exhibits cardioprotective and anticancer chemotherapeutic activities. In vivo, tubastatin A decreases levels of α-tubulin and protects against atrial fibrillation-related atrial remodeling. Additionally, tubastatin A restores expression of primary cilia and decreases cell proliferation and growth in cholangiocarcinoma cells; in similar animal models, this compound inhibits tumor growth.

Product Info

Cas No.	1310693-92-5
Purity	≥98%
Formula	C₂₀H₂₁N₃O₂ • HCl
Formula Wt.	371.86
IUPAC Name	N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride
Synonym	Tubastatin A HCl
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	T8006 Info Sheet PDF

References

Zhang D, Wu CT, Qi X, et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 2014 Jan 21;129(3):346-58. PMID: 24146251.

Gradilone SA, Radtke BN, Bogert PS, et al. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1;73(7):2259-70. PMID: 23370327.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂