WY-14643isaperoxisomeproliferator-activatedreceptoragoNISTthathasbeenfoundtoupregulatehepaticgeneexpressioninmouselivers.FurThermore,WY-14643hasbeenshowntoimproveproteasomalfunction,preventNF-kBactivation,anddecreaseoxidativestressinwild-typeandADIposetriglyceridelipaseknockoutmice.
| CasNo. | 50892-23-4 |
|---|---|
| Purity | ≥98% |
| Formula | C14H14ClN3O2S |
| FormulaWt. | 323.80 |
| IUPACName | ({4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}sulfanyl)aceticacid |
| Synonym | PirinixicAcid,WY14643 |
| MeltingPoint | 155-157°C |
| Solubility | DMSO(40mg/ml) |
| Appearance | Offwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | W9602InfoSheetPDF |
|---|
SzalowskaE,TesfayHA,vanHijumSA,KerstenS.Transcriptomicsignaturesofperoxisomeproliferator-activatedreceptor(PPAR)indifferentmouselivermodelsidentifynovelaspectsofitsBIOLOGy.BMCGenomics.2014Dec;15(1):1106.PMID:25511156.
MussbacherM,StesselH,WolkartG,etal.Roleoftheubiquitin-proteasomesystemincardiacdysfunctionofadiposetriglyceridelipase-deficientmice.JMolCellCardiol.2014Dec;77:11-19.PMID:25285770.
