Description
γ-Neuropeptide is an endogenous tachykinin/neurokinin peptide that binds neurokinin (NK) receptors, displaying some selectivity for NK2 isoforms. This peptide mediates hypothalamic-pituitary-adrenal (HPA) axis signaling and reproductive hormone release, inhibiting hypothalamic secretion of luteinizing hormone (LH). Additionally, γ-neuropeptide induces vasodilation and hypotensive activity in vivo. γ-Neuropeptide may play a role in gastrointestinal motility, as it stimulates smooth muscle contraction in the gastrointestinal tract; it also stimulates smooth muscle contraction in the respiratory tract. γ-Neuropeptide forms complexes with Cu(II) as well.
References
Pietruszka M, Jankowska E, Kowalik-Jankowska T, et al. Complexation abilities of neuropeptide gamma toward copper(II) ions and products of metal-catalyzed oxidation. Inorg Chem. 2011 Aug 15;50(16):7489-99. PMID: 21770367.
Kim EJ, Kim CH, Seo JK, et al. Structure-activity relationship of neuropeptide gamma derived from mammalian and fish. J Pept Res. 2005 Dec;66(6):395-403. PMID: 16316456.
Debeljuk L, Lasaga M. Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma. Peptides. 1999;20(2):285-99. PMID: 10422885.
Yuan L, Burcher E, Nail BS. Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit. Pulm Pharmacol Ther. 1998 Feb;11(1):31-9. PMID: 9802961.
