Aceclofenacisadiclofenacanalogthatexhibitsanti-inflammatoryandanalgesicactivities.Aceclofenacisanon-steroidalanti-inflammatorydrug(NSAID)thatsomewhatselectivelyinhibitsCOX-2;itisclinicallyusedtotreatrheumatoidarthritis,osteoarthritis,andankylosingspondylitis.AceclofenacdownregulatesexpressionofL-selectin,ICAM-3,andCD43,decreasingneutrophiladhesiontoendothelialcells.
| CasNo. | 89796-99-6 |
|---|---|
| Purity | ≥98% |
| Formula | C16H13Cl2NO4 |
| FormulaWt. | 354.18 |
| ChemicalName | 2-[(2,6-Dichlorophenyl)amino]benzeneaceticacidcarboxymethylester |
| IUPACName | 2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyaceticacid |
| Synonym | Airtal;Falcol;Gerbin;Preservex |
| MeltingPoint | 149-150°C |
| Solubility | Solubleinethanolandacetone,insolubleinwater |
| Appearance | AWhiteorAlmostWhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A1017MSDSPDF |
|---|---|
| InfoSheet | A1017InfoSheetPDF |
ChopadeAR,SayyadFJ,NaikwadeNS.Pharmacologicalcharacterizationofcarrageenaninducedheatmusclehyperalgesiainratsusingnon-selective,preferentialandselectiveCOX-2inhibitors.PharmacolRep.2014Jun;66(3):353-62.PMID:24905509.
González-AlvaroI,CarmonaL,Díaz-GonzálezF,etal.Aceclofenac,anewnonsteroidalantiinflammatorydrug,decreasestheexpressionandfunctionofsomeadhesionmoleculesonhumanneutrophils.JRheumatol.1996Apr;23(4):723-9.PMID:8730134.
