Acemetacinisaglycolicacidesterprodrugofindomethacin;itisanon-steroidalanti-inflammatorydrug(NSAID)thatinhibitsCOX-1andCOX-2,decreasingproductionofthromboxaneB2(TxB2)andprostaglandinE2(PGE2).Acemetacinisclinicallyusedtotreatrheumatoidarthritis,osteoarthritis,andpost-operativepain.Invitro,acemetacinalsoexhibitsantioxidativeactivity,scavengingROSandRNS.
| CasNo. | 53164-05-9 |
|---|---|
| Purity | ≥98% |
| Formula | C21H18ClNO6 |
| FormulaWt. | 415.83 |
| ChemicalName | 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-aceticacidcarboxymethylester |
| IUPACName | 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyaceticacid |
| Synonym | Acemix;Emflex;Rantudil;Solart |
| MeltingPoint | 150-153°C |
| Solubility | SolubleinDMSO. |
| Appearance | SlightlyYellowishCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A0816MSDSPDF |
|---|---|
| InfoSheet | A0816InfoSheetPDF |
Chávez-PiñaAE,McKnightW,DicayM,etal.Mechanismsunderlyingtheanti-inflammatoryactivityandgastricsafetyofacemetacin.BrJPharmacol.2007Nov;152(6):930-8.PMID:17876306.
FernandesE,CostaD,TosteSA,etal.Invitroscavengingactivityforreactiveoxygenandnitrogenspeciesbynonsteroidalanti-inflammatoryindole,pyrrole,andoxazolederivativedrugs.FreeRADIcBiolMed.2004Dec1;37(11):1895-905.PMID:15528048.
