Description
Adrenocorticotropichormone(ACTH)isapeptidederivedfromproopiomelanocortin(POMC)processedandsecretedinthepituitarygland.ACTHbindsandactivatesmelanocortin-2(MC2)receptors,stimulatingcortisolproductionintheadrenalcortex.ACTHexhibitsanti-inflammatoryandimmunomodulatoryactivities.ACTHdecreasesinflammatorycytokinelevelsandmodulateslymphocyteandmacrophagefunctions.Invitro,ACTHstimulatesproliferationofosteoblastsandincreasesmRNAlevelsofcollagenI.