LKT/ALENDRONATE MONOSODIUM TRIHYDRATE/A4515/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/ALENDRONATE MONOSODIUM TRIHYDRATE/A4515/100 mg

LKT/ALENDRONATE MONOSODIUM TRIHYDRATE/A4515/100 mg

商品编号： A4515-100mg

品牌： lktlabs

市场价： ¥1880.00

美元价： 1128.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDA4515

CasNo.121268-17-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Alendronateisasecondgenerationbisphosphonatethatexhibitsanti-resorptive,anti-inflammatory,immunomodulatory,andanticancerchemotherapeuticactivities.Alendronateinhibitsboneresorptionbutdoesnothaveanyeffectsonbonemineralization;italsoinhibitsosteoclastformationanddecreasesphosphorylationofAktandERK1/2invitro.Inanimalmodels,alendronatedecreasesproductionofTh4andTh17cytokinesandeotaxin-2,suppressingantigen-inducedpulmonaryimmuneresponses.Additionally,thiscompoundincreasesδγTcellactivationandinhibitstumorgrowthinvivo.

ProductInfo

CasNo.	121268-17-5
Purity	≥98%
Formula	C₄H₁₂NNaO₇P₂•3H₂O
FormulaWt.	325.08
ChemicalName	4-Amino-1-hydroxybutylidine-1,1-bisphosphate
IUPACName	sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate
Synonym	Alendronicacid;ABDP
MeltingPoint	233-235°C(dec)
Solubility	Solubleinwater(10mg/mL).PBS0.25mg/mL.DMSO<1>
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	A4515MSDSPDF
InfoSheet	A4515InfoSheetPDF

References

TsubakiM,KomaiM,ItohT,etal.Nitrogen-containingbisphosphonatesinhibitRANKL-andM-CSF-inducedosteoclastformationthroughtheinhibitionofERK1/2andAktactivation.JBiomedSci.2014Feb3;21:10.PMID:24490900.

SasakiO,ImamuraM,YamazumiY,etal.AlendronateattenuateseosinophilicairwayinflammationassociatedwithsuppressionofTh4cytokines,Th17cytokines,andeotaxin-2.JImmunol.2013Sep15;191(6):2879-89.PMID:23935198.

GutmanD,Epstein-BarashH,TsurielM,etal.Alendronateliposomesforantitumortherapy:activationofγδTcellsandinhibitionoftumorgrowth.AdvExpMedBiol.2012;733:165-79.PMID:22101722.

TakahashiH,KinbaraM,SatoN,etal.Nickelallergy-promotingeffectsofmicrobialorinflammatorysubstancesatthesensitizationstepinmice.IntImmunopharmacol.2011Oct;11(10):1534-1540.PMID:21621645.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂