Description
Alendronate is a second generation bisphosphonate that exhibits anti-resorptive, anti-inflammatory, immunomodulatory, and anticancer chemotherapeutic activities. Alendronate inhibits bone resorption but does not have any effects on bone mineralization; it also inhibits osteoclast formation and decreases phosphorylation of Akt and ERK1/2 in vitro. In animal models, alendronate decreases production of Th4 and Th17 cytokines and eotaxin-2, suppressing antigen-induced pulmonary immune responses. Additionally, this compound increases δγ T cell activation and inhibits tumor growth in vivo.
References
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Sasaki O, Imamura M, Yamazumi Y, et al. Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th4 cytokines, Th17 cytokines, and eotaxin-2. J Immunol. 2013 Sep 15;191(6):2879-89. PMID: 23935198.
Gutman D, Epstein-Barash H, Tsuriel M, et al. Alendronate liposomes for antitumor therapy: activation of γδ T cells and inhibition of tumor growth. Adv Exp Med Biol. 2012;733:165-79. PMID: 22101722.
Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.
