AlfacalcidolisavitaminDanalogthatrequires25-hydroxylationtobecometheactivehormonalformofvitaminD3.Alfacalcidolisclinicallyusedtotreatosteoporosis,hyperparathyroidism,andrenalbonedisease.Asananti-osteoporotic,alfacalcidolincreasesbonestrengthandformationanddisplaysanti-catabolicandanaboliceffectsonboneinvivo.
| CasNo. | 41294-56-8 |
|---|---|
| Purity | ≥98% |
| Formula | C27H44O2 |
| FormulaWt. | 400.64 |
| IUPACName | (1R,3S,5E)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
| Synonym | 1-HydroxyvitaminD3;1-Hydroxycholecalciferol(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol |
| MeltingPoint | 136°C |
| Solubility | SolubleinTHFandmethanol. |
| Appearance | WhiteCrystallinePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A4521InfoSheetPDF |
|---|
MazzaferroS,GoldsmithD,LarssonTE,etal.VitaminDMetabolitesand/orAnalogs:WhichDforWhichPatient?CurrVascPharmacol.2014Mar;12(2):339-49.PMID:23713876.
HaraS,KishimotoKN,OkunoH,etal.Effectsofalfacalcidolonbackextensorstrengthgainedthroughbackextensorexerciseinpostmenopausalwomenwithosteoporosis.AmJPhysMedRehABIl.2013Feb;92(2):101-10.PMID:23044701.
ChenH,TianX,LiuX,etal.Alfacalcidol-stimulatedfocalboneformationonthecancelloussurfaceandincreasedboneformationontheperiostealsurfaceofthelumbarvertebraeofadultfemalerats.CalcifTissueInt.2008Feb;82(2):127-36.PMID:18175034.
