α-Galactosylceramide is a synthetic glycolipid found in Agelas mauritanius and other marine sponges. α-Galactosylceramide exhibits immunostimulatory activity, binding CD1d on antigen-presenting cells such as NK cells. This compound is also used to tag or stain immune cells in research models.
| Cas No. | 158021-47-7 |
|---|---|
| Purity | ≥96% |
| Formula | C50H99NO9 |
| Formula Wt. | 858.34 |
| IUPAC Name | N-[(2S,3S,4R)-1-(α-D-Galactopyranosyloxy)-3,4-dihydroxy-2-octadecanyl]hexacosanamide |
| Synonym | alpha-Gal-Cer, KRN7000 |
| Solubility | Soluble in pyridine. Solubilization in Tween20 or PBS for cell culture use see online protocol. |
| Appearance | Off-white solid. |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Blue Ice |
| Info Sheet | G0244 Info Sheet PDF |
|---|---|
| Solubilization Protocol | G0244 Solubilization |
Zhang F, Zhu Z, Meadows GG, et al. Chronic alcohol consumption inhibits melanoma growth but decreases the survival of mice immunized with tumor cell lysate and boosted with α-galactosylceramide. Int Immunopharmacol. 2015 Sep;28(1):359-68. PMID: 26118634.
Macho-Fernandez E, Brigl M. The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol. 2015 Jul 28;6:362. PMID: 26284062.
Franck RW. C-Galactosylceramide: Synthesis and Immunology. C R Chim. 2012 Jan 1;15(1):46-56. PMID: 22408579.
