Aminopterinisafolicacidanalogandderivativeofpterin;itisverysimilartomethotrexateinstructure.Aminopterinexhibitsanticancerchemotherapeuticandimmunosuppressiveactivities.Likeotherfolicacidanalogs,aminopterininhibitsdihydrofolatereductase,depletingnucleotidepoolsandinhibitingsynthesisofDNAandRNA.Aminopterinwasoneofthefirstcompoundstosuccessfullyinduceremissioninchildhoodleukemiaandwasclinicallyusedtotreatrheumatoidarthritis,buthassincebeenreplacedbymethotrexate.
| CasNo. | 54-62-6 |
|---|---|
| Purity | ≥95% |
| Formula | C19H20N8O5 |
| FormulaWt. | 440.41 |
| ChemicalName | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamicacid |
| IUPACName | 2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioicacid |
| Synonym | 4-Aminofolicacid |
| MeltingPoint | 230-235°C(dec) |
| Solubility | SolubleinDMSOor2NNaOH(50mg/mL). |
| Appearance | DarkYellow-BrownPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5001MSDSPDF |
|---|---|
| InfoSheet | A5001InfoSheetPDF |
VisentinM,ZhaoR,GoldmanID.Theantifolates.HematolOncolClinNorthAm.2012Jun;26(3):629-48.PMID:22520983.
McGuireJJ.Anticancerantifolates:currentstatusandfuturedirections.CurrPharmDes.2003;9(31):2593-613.PMID:14529544.
BaggottJE,MorganSL,HaTS,etal.Antifolatesinrheumatoidarthritis:ahypotheticalmechanismofaction.ClinExpRheumatol.1993Mar-Apr;11Suppl8:S101-5.PMID:8324932.
