Tunicamycinisanucleosideantibioticmixturethatinhibitsglycoproteinsynthesis.TunicamycinpreventsN-glycosylationbyinhibitingGlcNAcphosphotransferaseandotherenzymes,inducingG1phasecellcyclearrestinvitro.Tunicamycindisplaysanti-inflammatoryactivity,inhibitingtoll-likereceptor(TLR)activation-inducedinflammationbydecreasingactivationofNF-κB,activityofCRE,andexpressionofiNOS,COX-2,TNF-α,andIL-1βinmacrophages.
| CasNo. | 11089-65-9 |
|---|---|
| Purity | ≥98% |
| Formula | C40H66N4O16 |
| FormulaWt. | Avg.840.0 |
| IUPACName | (E)-N-[(2R,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-5-methylhex-2-enamide |
| MeltingPoint | 234-235°C |
| Solubility | SolubleinDMSOandDMF. |
| Appearance | WhiteSolid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | T8153MSDSPDF |
|---|---|
| InfoSheet | T8153InfoSheetPDF |
KimSY,HwangJS,HanIO.TunicamycininhibitsToll-likereceptor-activatedinflammationinRAW264.7cellsbysuppressionofNF-κBandc-JunactivityviaamechanismthatisindependentofER-stressandN-glycosylation.EurJPharmacol.2013Dec5;721(1-3):294-300.PMID:24056124.
PertusaM,MadridR,Morenilla-PalaoC,etal.N-glycosylationofTRPM8ionchannelsmodulatestemperaturesensitivityofcoldThermoreceptorneurons.JBiolChem.2012May25;287(22):18218-29.PMID:22493431.
