Description
Tyr-W-MIF-1isaneuromodulatorypeptideoftheMIF-1familythatactsasanantagoNISTatμ2-opioidreceptors(μORs).Whengivenalone,Tyr-W-MIF-1inducesmixed,dose-dependenteffectsonμORs;Tyr-W-MIF-1inhibitstheanalgesicandantinociceptiveactivitiesofopioidswhenco-administered.Thispeptideinhibitsstress-inducedsecretionofadrenocorticotropichormone(ACTH)andcorticosterone.Tyr-W-MIF-1mayalsomodulaterewardprocessingthroughitsactivitiesatopioidreceptors,asitinducesconditionedplacepreferenceinanimalmodelswhendeliveredalone.
References
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