Description
Tyr-W-MIF-1 is a neuromodulatory peptide of the MIF-1 family that acts as an antagonist at μ2-opioid receptors (μORs). When given alone, Tyr-W-MIF-1 induces mixed, dose-dependent effects on μORs; Tyr-W-MIF-1 inhibits the analgesic and antinociceptive activities of opioids when co-administered. This peptide inhibits stress-induced secretion of adrenocorticotropic hormone (ACTH) and corticosterone. Tyr-W-MIF-1 may also modulate reward processing through its activities at opioid receptors, as it induces conditioned place preference in animal models when delivered alone.
References
Mizoguchi H, Takagi H, Watanabe C, et al. Involvement of multiple μ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission. Peptides. 2013 Oct 25. pii: S0196-9781(13)00344-6. PMID: 24512946.
Bocheva A, Dzambazova E, Hadjiolova R, et al. Effect of Tyr-MIF-1 peptides on blood ACTH and corticosterone concentration induced by three experimental models of stress. Auton Autacoid Pharmacol. 2008 Oct;28(4):117-23. PMID: 18798907.
Bocheva A, Dzambazova-Maximova E. Antiopioid properties of the TYR-MIF-1 family. Methods Find Exp Clin Pharmacol. 2004 Nov;26(9):673-7. PMID: 15632952.
Nores WL, Olson RD, Olson GA, et al. Tyr-W-MIF-1-induced conditioned place preference. Peptides. 1999;20(4):479-84. PMID: 10458518.
