U-74389G is an antioxidant that exhibits free radical-scavenging protective effects on ischemia/reperfusion injured liver in Wistar rat models. Short-term administration has been shown to improve renal function. It has also been demonstrated to produce an anti-inflammatory activity in the Wistar rat model of colitis.
| Cas No. | 153190-29-5 |
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| Purity | ≥95% |
| Formula | C37H50N6O2・C4H4O4 |
| Formula Wt. | 726.92 |
| Chemical Name | 21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate salt |
| IUPAC Name | (8S,10S,13S,14S,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13-dimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one |
| Synonym | U74389G; U-74389G maleate |
| Solubility | Soluble in DMSO(25 mg/ml) and ethanol (25 mg/ml). |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | U8000 Info Sheet PDF |
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Bonatsos V, Kappas I, Birbas K, et al. Effects of U-74389G (21-Lazaroid) and ascorbic acid on liver recovery after acute ischemia and reperfusion in rats. In Vivo. 2015 Sep-Oct; 29(5):585-594. PMID: 26359418.
Tsompos C, Panoulis C, Toutouzas K, et al. The effect of the antioxidant drug “U-74389G” on creatinine levels during ischemia reperfusion injury in rats. Curr Urol. 2016 May; 9(2):73-78. PMID: 27390579.
Margonis GA, Christoloukas N, Antoniou E, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb; 193(2):667-674. PMID: 25277360.
