Description
UrocortinIIisanendogenouspeptideligandandmemberofthecorticotropin-releasingfactor(CRF)family;itbindsandactivatesCRFtype2receptors.Likeotherurocortins,urocortinIImodulatesstressresponsesandexhibitsanorexigenic,anxiogenic,anxiolytic,andpositiveinotropiceffects(includingincreasesincoronarybloodblowandcardiacoutput)acrossawidevarietyofinvivomodels.UrocortinIImodulatesCa2+homeostasisincellularmodels.Additionally,urocortinIIinducesdepolarizationofpathogencellmembranes,exhibitingantibacterialactivity.
References
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