UrocortinIIIisanendogenouspeptideligandandmemberofthecorticotropin-releasingfactor(CRF)family;itbindsandactivatesCRFtype2receptors.UrocortinIIIisexpressedprimarilyinbrainregionssuchasthehypothalamus(specificallythepituitarygland),butisalsopresentinheart,kidney(adrenalglands),andgastrointestinaltissues.UrocortinIIImodulatesstressresponsesandexhibitsanorexigenic,anxiogenic,anxiolytic,andpositiveinotropiceffectsacrossawidevarietyofinvivomodels.
| Purity | ≥95% |
|---|---|
| Formula | C186H312N52O52S2 |
| FormulaWt. | 4173.01 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | U6860InfoSheetPDF |
|---|
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TakahashiK,TotsuneK,MurakamiO,etal.Urocortinsascardiovascularpeptides.Peptides.2004Oct;25(10):1723-31.PMID:15476939.
SudaT,KageyamaK,SakiharaS,etal.Physiologicalrolesofurocortins,humanhomologuesoffishurotensinI,andtheirreceptors.Peptides.2004Oct;25(10):1689-701.PMID:15476936.
