Urocortinisanendogenouspeptideligandandmemberofthecorticotropin-releasingfactor(CRF)family;itbindsandactivatesCRFtype1and2receptors.Urocortinmodulatesstressresponsesandexhibitsanorexigenic,anxiogenic,andpositiveinotropiceffectsacrossawidevarietyofinvivomodels.Urocortinisprimarilyexpressedintheheart.Urocortinexertsmanyeffectsonsignalingofthehypothalamic-pituitary-adrenal(HPA)axis,includingincreasingcorticosteroneandadrenocorticotropichormone(corticotropin)levels.
| Purity | ≥95% |
|---|---|
| Formula | C206H338N62O64 |
| FormulaWt. | 4707.37 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | U6855InfoSheetPDF |
|---|
BagosiZ,CsabafiK,PalotaiM,etal.TheeffectofurocortinIonthehypothalamicACTHsecretagoguesanditsimpactonthehypothalamic-pituitary-adrenalaxis.Neuropeptides.2013Nov21.pii:S0143-4179(13)00100-5.PMID:24331779.
DonoLM,CurriePJ.ThecannABInoidreceptorCB1inverseagoNISTAM251potentiatestheanxiogenicactivityofurocortinIinthebasolateralamygdala.Neuropharmacology.2012Jan;62(1):192-9.PMID:21736884.
CurriePJ,CoiroCD,DuenasR,etal.UrocortinIinhibitstheeffectsofghrelinandneuropeptideYonfeedingandenergysubstrateutilization.BrainRes.2011Apr18;1385:127-34.PMID:21303672.
TakahashiK,TotsuneK,MurakamiO,etal.Urocortinsascardiovascularpeptides.Peptides.2004Oct;25(10):1723-31.PMID:15476939.
SudaT,KageyamaK,SakiharaS,etal.Physiologicalrolesofurocortins,humanhomologuesoffishurotensinI,andtheirreceptors.Peptides.2004Oct;25(10):1689-701.PMID:15476936.
