UrotensinIIisapeptideligandthatbindstheurotensinII(UT)receptorandcanbeusedasabioMarkerforhypertensionandtype2diabetes.UrotensinIIincreasesexpressionofIL-6,IL-1β,VCAM-1,andtissuefactorinvitro,exhibitingpro-inflammatoryactivity.UrotensinIIalsoinhibitsglucosetransportthroughmodulationofNADPHoxidasesignaling,whichincreaseslevelsofROSanddecreasesphosphorylationofAkt,ERK1/2,andp38MAPK.Additionally,urotensinIIcaninduceapoptosisincardiactissuecellsandcaninducerelaxationinsmoothmusclecells.
| Purity | ≥95% |
|---|---|
| Formula | C64H85N13O18S2 |
| FormulaWt. | 1388.6 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | U6959InfoSheetPDF |
|---|
PengH,ZhangM,CaiX,etal.AssociationbetweenHumanUrotensinIIandEssentialHypertension-A1:1MatchedCase-ControlStudy.PLoSOne.2013Dec10;8(12):e81764.PMID:24339964.
WangHX,WuXR,YangH,etal.UrotensinIIinhibitsskeletalmuscleglucosetransportsignalingpathwaysviatheNADPHoxidasepathway.PLoSOne.2013Oct8;8(10):e76796.PMID:24116164.
ParkSL,LeeBK,KimYA,etal.InhibitoryEffectofanUrotensinIIReceptorAntagoNISTonProinflammatoryActivationInducedbyUrotensinIIinHumanVascularEndothelialCells.BiomolTher(Seoul).2013Jul30;21(4):277-83.PMID:24244812.
