Valdecoxib is a COX inhibitor specific for COX-2; it also inhibits carbonic anhydrase. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities. In addition to its mediation of inflammatory signaling, valdecoxib also activates cannabinoid 1 (CB1) receptors in vivo, modulating glutamate signaling and GABA release. Valdecoxib has been removed from clinical use due to increased risk of thrombotic effects.
| Cas No. | 181695-72-7 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14N2O3S |
| Formula Wt. | 314.36 |
| IUPAC Name | 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide |
| Melting Point | 162-164℃ |
| Solubility | Water 0.5 mg/ml |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | V0245 Info Sheet PDF |
|---|
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Benetello V, Sakamoto FC, Giglio FP, et al. The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal. Braz J Med Biol Res. 2007 Aug;40(8):1133-40. PMID: 17665051.
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Walker MC, Kurumbail RG, Kiefer JR, et al. A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem J. 2001 Aug 1;357(Pt 3):709-18. PMID: 11463341.
