VX-765isaninhibitorofNLRP3inflammasomeactivity;itinhibitscaspase1andIL-1βcleavageandrelease.VX-765exhibitsanti-inflammatory,antidepressant,andantiepilepticactivities.Invivo,thiscompounddecreasesIL-1βlevelsandattenuatesstress-induceddepression-likebehaviors.Inanimalmodelsofstatusepilepticus,VX-765decreasescellloss.Inothersimilaranimalmodels,thiscompounddecreaseschronicepilepticactivityanddelaysonsetofacuteseizures.
| CasNo. | 273404-37-8 |
|---|---|
| Purity | ≥98% |
| Formula | C24H33ClN4O6 |
| FormulaWt. | 509.00 |
| IUPACName | N-(4-Amino-3-chlorobenzoyl)-3-methylvalyl-N-[(2R,3S)-2-ethoxy-5-oxotetrahydro-3-furanyl]-L-prolinamide |
| Synonym | VX765 |
| Appearance | Lightyellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | V9228InfoSheetPDF |
|---|
ZhangY,LiuL,LiuYZ,etal.NLRP3InflammasomeMediatesChronicMildStress-inducedDepressioninMiceviaNeuroinflammation.IntJNeuropsychopharmacol.2015Jan20.[Epubaheadofprint].PMID:25603858.
KaminskiRM,RogawskiMA,KlitgaardH.Thepotentialofantiseizuredrugsandagentsthatactonnovelmoleculartargetsasantiepileptogenictreatments.Neurotherapeutics.2014Apr;11(2):385-400.PMID:24671870.
NoeFM,PolascheckN,FrigerioF,etal.PharmacologicalblockadeofIL-1β/IL-1receptortype1axisduringepileptogenesisprovidesneuroprotectionintworatmodelsoftemporallobeepilepsy.NeurobiolDis.2013Nov;59:183-93.PMID:23938763.
MarosoM,BalossoS,RavizzaT,etal.Interleukin-1βbiosynthesisinhibitionreducesacuteseizuresanddrugresistantchronicepilepticactivityinmice.Neurotherapeutics.2011Apr;8(2):304-15.PMID:21431948.
