Description
WH-4-023 inhibits Lck, Src, and SIK. In macrophage models, this compound exhibits immunomodulatory activity, inhibiting T cell activation and increasing IL-10 production.
LKT/WH-4-023/W2800/5 mg
市场价：
¥3700.00
美元价：
2220.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product ID W2800
Cas No. 837422-57-8
Purity ≥99 %
- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Product Info
| Cas No. | 837422-57-8 |
|---|---|
| Purity | ≥99 % |
| Formula | C32H36N6O4 |
| Formula Wt. | 568.68 |
| IUPAC Name | 2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)carbamate |
| Synonym | KIN112 |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| Info Sheet | W2800 Info Sheet PDF |
|---|
References
Clark K, MacKenzie KF, Petkevicius K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. PMID: 23033494.
Martin MW, Newcomb J, Nunes JJ, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID: 16884310.
品牌介绍
LKT Labs
LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。
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