Xenin is an endogenous neurotensin-related peptide hormone that exhibits anorexigenic activity, suppressing feeding behavior in vivo in an IL-1R-dependent manner. Xenin also induces relaxation in ileal smooth muscle cells through activity at neurotensin-type apamin-sensitive receptors. Xenin also delays gastric emptying in vivo, likely contributing to its effects on feeding behavior.
| Purity | ≥95% |
|---|---|
| Formula | C139H224N38O32S |
| Formula Wt. | 2971.63 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | X1752 Info Sheet PDF |
|---|
Kim ER, Xu Y, Mizuno TM. Impaired suppression of feeding by the gut hormone xenin in type I interleukin-1 receptor-deficient mice. Behav Brain Res. 2013 Dec 12;261C:60-64. PMID: 24333379.
Kim ER, Mizuno TM. Xenin delays gastric emptying rate and activates the brainstem in mice. Neurosci Lett. 2010 Aug 30;481(1):59-63. PMID: 20599589.
Alexiou C, Zimmermann JP, Schick RR, et al. Xenin--a novel suppressor of food intake in rats. Brain Res. 1998 Aug 3;800(2):294-9. PMID: 9685684.
Clemens A, Katsoulis S, Nustede R, et al. Relaxant effect of xenin on rat ileum is mediated by apamin-sensitive neurotensin-type receptors. Am J Physiol. 1997 Jan;272(1 Pt 1):G190-6. PMID: 9038893.
