Zearalenoneisanon-steroidmycotoxininitiallyproducedbyspeciesofFusariumthatoccursasacontaminantingrainproductssuchascereal.Zearalenoneexhibitsestrogeniceffects,activatingestrogenreceptors.Invivo,zearalenonecauseshormonaleffectsandabnormalreproductivedevelopment.Inmalegermcellssuchasspermatocytesandspermatogonia,zearalenoneinducesapoptosis.Inotherinvitromodels,thiscompoundinducesoxidativestressandcytotoxicity,alteringlevelsofglutathione,TBARS,andHSP70.
| CasNo. | 17924-92-4 |
|---|---|
| Purity | ≥98% |
| Formula | C18H22O5 |
| FormulaWt. | 318.36 |
| IUPACName | (2E,11S)-15,17-dihydroxy-11-methyl-12-oxABIcyclo[12.4.0]octadeca-1(14),2,15,17-tetraene-7,13-dione |
| MeltingPoint | 159-163°C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | Z1602InfoSheetPDF |
|---|
LeeH,KangC,YooYS,etal.CytotoxicityandtheinductionofthestressproteinHsp70inChanglivercellsinresponsetozearalenone-inducedoxidativestress.EnvironToxicolPharmacol.2013Sep;36(2):732-40.PMID:23917164.
ProuillacC,KoraichiF,VidemannB,etal.Invitrotoxicologicaleffectsofestrogenicmycotoxinsonhumanplacentalcells:structureactivityrelationships.ToxicolApplPharmacol.2012Mar15;259(3):366-75.PMID:22310176.
KimIH,SonHY,ChoSW,etal.Zearalenoneinducesmalegermcellapoptosisinrats.ToxicolLett.2003Mar3;138(3):185-92.PMID:12565195.
BoydPA,WittliffJL.MechanismofFusariummycotoxinactioninmammarygland.JToxicolEnvironHealth.1978Jan;4(1):1-8.PMID:633402.
