βMelanocyte-stimulatinghormone(βMSH)isanendogenousPOMC-derivedpeptideinthepituitaryinvolvedinenergyhomeostasisthatactivatesmelanocortinreceptors.βMSHexhibitsanti-inflammatoryandanorexigenicactivities.Invivo,βMSHdecreasestheintensityofacetaminophen-inducedliverlesions.Inotheranimalmodels,thispeptideincreasesorexinandcorticotropin-releasingfactor(CRF)levelsanddecreasesfoodintake.
| CasNo. | 17908-57-5 |
|---|---|
| Purity | ≥98% |
| Formula | C118H174N34O35S |
| FormulaWt. | 2660.9 |
| IUPACName | L-Alanyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-aspartyl-L-α-glutamylglycyl-L-prolyl-L-tyrosyl-N5-(diaminomethylene)-L-ornithyl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-N5-(diaminomethylene)-L-ornithyl-L-tryptophylglycyl-L-seryl-L-prolyl-L-prolyl-L-lysyl-L-asparticacid |
| Synonym | β-MSH |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M7529InfoSheetPDF |
|---|
BlagaićV,HouraK,TurcićP,etal.Theinfluenceofalpha-,beta-,andgamma-melanocytestimulatinghormoneonacetaminopheninducedliverlesionsinmaleCBAmice.Molecules.2010Mar3;15(3):1232-41.PMID:20335976.
KamisoyamaH,HondaK,SaneyasuT,etal.Corticotropin-releasingfactorisadownstreammediatorofthebeta-melanocyte-stimulatinghormone-inducedanorexigenicpathwayinchicks.NeurosciLett.2009Jul24;458(3):102-5.PMID:19393716.
