AdrenorphinisanendogenousopioidpeptideproducedfromcleavageofproenkephalinA.AdrenorphinactsasanagoNISTatκ-opioidreceptors(κORs)andμ-opioidreceptors(μORs).Likeotheropioids,adrenorphinexhibitsanalgesic,antinociceptive,andgastrointestinalmotilitymodulatingactivities.Adrenorphinalsocausesrespiratorydepressioninanimalmodels.Inpheochromocytomacells,adrenorphininhibitscatecholaminesecretion.Inanimalmodels,italsoinhibitsurinarybladdermusclecontractions.
| Purity | ≥95% |
|---|---|
| Formula | C44H69N15O9S |
| FormulaWt. | 984.2 |
| IUPACName | (2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-N-[(2R)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-5-(diaminomethylideneamino)pentanamide |
| Synonym | Metorphamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A1371InfoSheetPDF |
|---|
YanaseT,NawataH,KatoK,etal.Studiesonadrenorphininpheochromocytoma.JClinEndocrinolMetab.1987Apr;64(4):692-7.PMID:3818899.
XuSF,LuWX,ZhouKR,etal.Theanalgesicandrespiratorydepressantactionsofmetorphamideinmiceandrabbits.Neuropeptides.1985Apr;6(2):121-31.PMID:4000426.
DrayA,DavisTP.TheproenkephalinAfragmentmetorphamideshowssupraspinalandspinalopioidactivityinvivo.Peptides.1985Mar-Apr;6(2):217-21.PMID:3839922.
WeberE,EschFS,BöhlenP,etal.Metorphamide:isolation,structure,andBIOLOGicactivityofanamidatedopioidoctapeptidefrombovinebrain.ProcNatlAcadSciUSA.1983Dec;80(23):7362-6.PMID:6316361.
