Description
Adrenorphin is an endogenous opioid peptide produced from cleavage of proenkephalin A. Adrenorphin acts as an agonist at κ-opioid receptors (κORs) and μ-opioid receptors (μORs). Like other opioids, adrenorphin exhibits analgesic, antinociceptive, and gastrointestinal motility modulating activities. Adrenorphin also causes respiratory depression in animal models. In pheochromocytoma cells, adrenorphin inhibits catecholamine secretion. In animal models, it also inhibits urinary bladder muscle contractions.
References
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Xu SF, Lu WX, Zhou KR, et al. The analgesic and respiratory depressant actions of metorphamide in mice and rabbits. Neuropeptides. 1985 Apr;6(2):121-31. PMID: 4000426.
Dray A, Davis TP. The proenkephalin A fragment metorphamide shows supraspinal and spinal opioid activity in vivo. Peptides. 1985 Mar-Apr;6(2):217-21. PMID: 3839922.
Weber E, Esch FS, Böhlen P, et al. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7362-6. PMID: 6316361.
