Description
Amylinisalsoknownasisletamyloidprecursorpeptide(IAPP)andisco-secretedwithinsulinfrompancreaticβ-cells.Amylinisanendogenouspeptidehormonethatexhibitsgastrointestinalmotilitymodulatingactivity,decreasinggastricemptyingandsuppressinggastricacidsecretion;theseactionsslowfoodintake,preventingbloodglucosespikesaftereatinganddecreasinginsulindemand.MisguidedIAPPprocessingplaysasignificantroleinthedevelopmentofdiabetesmellitustype2.Likecalcitonin,IAPPinhibitsosteoclastactivityandCa2+reabsorptioninbones.Thispeptidebindstocalcitonin-RAMPcomplexes.