Description
Benfotiamineisasynthetic,lipid-solublederivativeoftheBvitaminthiamine.Benfotiamineexhibitsantinociceptive,neuroprotective,andanti-inflammatoryactivities.Inanimalmodels,benfotiamineinhibitspainsignalinginaprostaticacidphosphatase-dependentmanner.Invitro,benfotiaminedecreasesproductionofamyloid-β(Aβ)anddownregulatesactivityofglycogensynthasekinase3(GSK3).Inmacrophages,thiscompoundinhibitsLPS-inducedactivationofphospholipaseA2(PLA2),releaseofleukotrienes,prostaglandins,andthromboxaneB2(TxB2),andalsosuppressesoxidativestress.Benfotiaminealsodecreasesoxidativestressinducedbystreptozocininanimalmodels.
References
HurtJK,ColemanJL,FitzpatrickBJ,etal.Prostaticacidphosphataseisrequiredfortheantinociceptiveeffectsofthiamineandbenfotiamine.PLoSOne.2012;7(10):e48562.PMID:23119057.
SunXJ,ZhaoL,ZhaoN,etal.Benfotiaminepreventsincreasedβ-amyloidproductioninHEKcellsinducedbyhighglucose.NeurosciBull.2012Oct;28(5):561-6.PMID:22961478.
ShoebM,RamanaKV.Anti-inflammatoryeffectsofbenfotiaminearemediatedthroughtheregulationofthearachidonicacidpathwayinmacrophages.FreeRADIcBiolMed.2012Jan1;52(1):182-90.PMID:22067901.
WuS,RenJ.Benfotiaminealleviatesdiabetes-inducedcerebraloxidativedamageindependentofadvancedglycationend-product,tissuefactorandTNF-alpha.NeurosciLett.2006Feb13;394(2):158-62.PMID:16260089.
