Description
Bisdemethoxycurcumin, like its parent compound curcumin, exhibits anticancer, antioxidative, anti-diabetic, anti-inflammatory, and antibacterial activities. Bisdemethoxycurcumin inhibits Wnt signaling by inhibiting WIF-1 promoter demethylation and inhibits DNA methyltransferase 1 (DNMT1), inducing apoptosis in non-small cell lung cancer (NSCLC) cells. Bisdemethoxycurcumin also induces apoptosis in other in vitro cancer models through increases in reactive oxygen species (ROS) and increases in the expression of p53, p21, p16, and retinoblastoma (Rb) protein. This compound activates SIRT1 and AMPK signaling. Bisdemethoxycurcumin inhibits PDGF signaling in smooth muscle cells, preventing cell migration and proliferation. Bisdemethoxycurcumin may also display potential benefit in the treatment of type 2 diabetes, as it acts as a noncompetitive inhibitor of pancreatic α-amylase. Like other curcuminoids, this compound also displays phototoxic antibacterial activity, although it is active primarily against gram-positive bacteria only.
References
Li YB, Zhong ZF, Chen MW, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. Epub 2013 Sep 2. PMID: 24078830.
Li YB, Gao JL, Zhong ZF, et al. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013;65(3):700-9. PMID: 23950593.
Hua Y, Dolence J, Ramanan S, et al. Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 2013 Sep;57(9):1611-8. PMID: 23554078.
Ponnusamy S, Zinjarde S, Bhargava S, et al. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 2012 Dec 15;135(4):2638-42. PMID: 22980852.
Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 2011 Nov;11(9):1098-110. PMID: 21933103.
Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.
