BVT-2733isaninhibitorof11β-hydroxysteroiddehydrogenase1(11β-HSD1)thatexhibitsanti-diabetic,anti-inflammatory,andanti-osteoporoticproperties.BVT-2733decreasesbloodglucoseandseruminsulinlevelsinanimalmodelsofhyperglycemia.BVT-2733alsoattenuatesarthritisseverity,decreasespro-inflammatorycytokineproduction,andsuppressessynovialinflammation.Inotheranimalmodels,thiscompoundprevents11βHSD-inducedosteogenicdifferentiationandsuppressionofosteogenesis.
| CasNo. | 376640-41-4 |
|---|---|
| Purity | ≥98% |
| Formula | C17H21ClN4O3S2 |
| FormulaWt. | 428.96 |
| IUPACName | 3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide |
| Synonym | BVT2733 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B8676InfoSheetPDF |
|---|
ZhangL,DongY,ZouF,etal.11β-Hydroxysteroiddehydrogenase1inhibitionattenuatescollagen-inducedarthritis.IntImmunopharmacol.2013Nov;17(3):489-94.PMID:23938253.
WuL,QiH,ZhongY,etal.11β-Hydroxysteroiddehydrogenasetype1selectiveinhibitorBVT.2733protectsosteoblastsagainstendogenousglucocorticoidinduceddysfunction.EndocrJ.2013;60(9):1047-58.PMID:23759754.
AlbertsP,EngblomL,EdlingN,etal.Selectiveinhibitionof11beta-hydroxysteroiddehydrogenasetype1decreasesbloodglucoseconcentrationsinhyperglycaemicmice.Diabetologia.2002Nov;45(11):1528-32.PMID:12436336.
