Description
Cefaclor is a second generation β-lactam cephalosporin antibiotic. Cefaclor exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefaclor also displays immunomodulatory and gastrointestinal motility modulating activities. Cefaclor enhances phagocytosis and bactericidal activity of granulocytes and macrophages and increases T lymphocyte activity. Additionally, this compound slows gastric emptying and intestinal transit by stimulating release of cholestocystokinin (CCK).
References
Berti AD, Sakoulas G, Nizet V, et al. β-Lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Oct;57(10):5005-12. PMID: 23896478.
Dabrowski MP, Stankiewicz W. Desirable and undesirable immunotropic effects of antibiotics: immunomodulating properties of cefaclor. J Chemother. 2001 Dec;13(6):615-20. PMID: 11806622.
Bozkurt A, Deniz M, Yegen BC. Cefaclor, a cephalosporin antibiotic, delays gastric emptying rate by a CCK-A receptor-mediated mechanism in the rat. Br J Pharmacol. 2000 Oct;131(3):399-404. PMID: 11015288.
