LKT/CHONDROITIN SULFATE, CHICKEN/C2961/25 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/CHONDROITIN SULFATE, CHICKEN/C2961/25 g

LKT/CHONDROITIN SULFATE, CHICKEN/C2961/25 g

商品编号： C2961-25g

品牌： lktlabs

市场价： ¥4320.00

美元价： 2592.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC2961

CasNo.9007-28-7

Purity≥90%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Chondroitinsulfate(CS)isapolyanionicsulfatedglycosaminoglycanthatdisplaysanti-arthritic,antioxidative,andanti-inflammatoryactivities.CSisanendogenouscomponentoftheextracellularmatrixofconnectivetissuesandisresponsIBLefortheirresistanceandelasticity.CSisoftenusedasadietarysupplement,althoughitsoralbioavailABIlityisquitelow(10-20%).Invivo,CSdecreasessynovitisandlevelsofIL-6,TNF-α,IL-1β,andmyeloperoxidase.CSmayactontoll-likereceptor4(TLR4),preventingactivationofNF-κBandinhibitingTNFreceptorassociationfactor6(TRAF6).Incellularandanimalmodels,CSincreasessynthesisofcollagen,proteoglycan,andhyaluronicacid;italsodownregulatesexpressionofmatrixmetalloproteinases1,3,and13.Invitro,CSincreaseslevelsofglutathioneandsuperoxidedismutaseandinhibitsactivationofcaspases3and7,decreasinglevelsofROS.

ProductInfo

CasNo.	9007-28-7
Purity	≥90%
Formula	C₁₃H₂₁NO₁₅S
FormulaWt.	~50,000Da
IUPACName	(2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylicacid
Synonym	Chondroitinsulfuricacid;Chonsurid;Structum
MeltingPoint	190-194°C
Solubility	Solubleinwater.
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	C2961InfoSheetPDF

References

HenrotinY,MathyM,SanchezC,etal.Chondroitinsulfateinthetreatmentofosteoarthritis:frominvitrostudiestoclinicalrecommendations.TherAdvMusculoskeletDis.2010Dec;2(6):335-48.PMID:22870459.

CampoGM,AvenosoA,CampoS,etal.GlycosaminoglycansmodulateinflammationandapoptosisinLPS-treatedchondrocytes.JCellBiochem.2009Jan1;106(1):83-92.PMID:19009563.

CampoGM,AvenosoA,CampoS,etal.Chondroitin-4-sulphateinhibitsNF-kBtranslocationandcaspaseactivationincollagen-inducedarthritisinmice.OsteoarthritisCartilage.2008Dec;16(12):1474-83.PMID:18501644.

ChouMM,VergnolleN,McDougallJJ,etal.Effectsofchondroitinandglucosaminesulfateinadietarybarformulationoninflammation,interleukin-1beta,matrixmetalloprotease-9,andcartilagedamageinarthritis.ExpBiolMed(Maywood).2005Apr;230(4):255-62.PMID:15792947.

ChoSY,SimJS,JeongCS,etal.EffectsoflowmolecularweightchondroitinsulfateontypeIIcollagen-inducedarthritisinDBA/1Jmice.BiolPharmBull.2004Jan;27(1):47-51.PMID:14709897.

CampoGM,AvenosoA,CampoS,etal.Efficacyoftreatmentwithglycosaminoglycansonexperimentalcollagen-inducedarthritisinrats.ArthritisResTher.2003;5(3):R122-31.PMID:12723984.

OmataT,ItokazuY,InoueN,etal.Effectsofchondroitinsulfate-Conarticularcartilagedestructioninmurinecollagen-inducedarthritis.Arzneimittelforschung.2000Feb;50(2):148-53.PMID:10719618.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂