Ciglitazoneisathiazolidinedionethatexhibitsantihypertensive,anticancer,andanti-diabeticactivities.CiglitazoneactsasanagoNISTatPPARγreceptors,decreasinginsulinlevels,VEGFproduction,andbloodpressure.Incellularmodelsofstomachcancer,ciglitazoneinducesG1phasecellcyclearrest,inhibitsERKphosphorylation,andsuppressescellgrowth.
| CasNo. | 74772-77-3 |
|---|---|
| Purity | ≥98% |
| Formula | C18H23NO3S |
| FormulaWt. | 333.45 |
| ChemicalName | (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione |
| IUPACName | 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| MeltingPoint | 114-130°C |
| Solubility | SolubleinDMSOorethanol. |
| Appearance | Tansolid |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C3210InfoSheetPDF |
|---|
ShahDK,MenonKM,CabreraLM,etal.Thiazolidinedionesdecreasevascularendothelialgrowthfactor(VEGF)productionbyhumanluteinizedgranulosacellsinvitro.FertilSteril.2010Apr;93(6):2042-7.PMID:19342033.
CheonCW,KimDH,KimDH,etal.Effectsofciglitazoneandtroglitazoneontheproliferationofhumanstomachcancercells.WorldJGastroenterol.2009Jan21;15(3):310-20.PMID:19140230.
PershadsinghHA,SzollosiJ,BensonS,etal.Effectsofciglitazoneonbloodpressureandintracellularcalciummetabolism.Hypertension.1993Jun;21(6Pt2):1020-3.PMID:8505086.
