CimetidineisanantihistaminethatinhibitsH2histaminereceptors,exhibitingantacidandanticancerchemotherapeuticactivities.CimetidineinhibitscatalaseactivityandalsoactsasanantagoNISTatandrogenreceptors.Cimetidineincreasestheefficacyofchemotherapeuticcompoundswhenadministeredconcurrently;inanimalmodelsoflungcancer,itincreasesexpressionofIFN-γandFas,inhibitingtumorgrowth.
| CasNo. | 51481-61-9 |
|---|---|
| Purity | ≥98% |
| Formula | C10H16N6S |
| FormulaWt. | 252.34 |
| ChemicalName | N-Cyano-N"-methyl-N""-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine |
| IUPACName | 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine |
| Synonym | Acibilin;Acinil;Cimetag;Edalene;Eureceptor;Gastromet;Peptol;Ulcerfen;Ulcomet |
| MeltingPoint | 141-143°C |
| Solubility | Solubleinwaterat37oC. |
| Appearance | AWhiteorAlmostWhiteCrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C3250MSDSPDF |
|---|---|
| InfoSheet | C3250InfoSheetPDF |
MasoudM,EbrahimiF,Minai-TehraniD.EffectofCimetidineonCatalaseActivityofPseudomonasaeruginosa:ASuggestedMechanismofAction.JMolMicrobiolBiotechnol.2014Jul2;24(3):196-201.PMID:24993120.
ZhengY,XuM,LiX,etal.Cimetidinesuppresseslungtumorgrowthinmicethroughproapoptosisofmyeloid-derivedsuppressorcells.MolImmunol.2013May;54(1):74-83.PMID:23220070.
MatsumotoS,ImaedaY,UmemotoS,etal.CimetidineincreasessurvivalofcolorectalcancerpatientswithhighlevelsofsialylLewis-XandsialylLewis-Aepitopeexpressionontumourcells.BrJCancer.2002Jan21;86(2):161-7.PMID:11870500.
RichardsDA.Comparativepharmacodynamicsandpharmacokineticsofcimetidineandranitidine.JClinGastroenterol.1983;5Suppl1:81-90.PMID:6317740.
