Clemizole is an inhibitor of transient receptor potential cation 5 (TRPC5) channels, NS4B, and histamine H1 receptors; it displays antiviral, anticonvulsant, anti-inflammatory, and anti-allergic activities. Clemizole suppresses replication of hepatitis C virus (HCV) and prevents convulsive behaviors and seizures in vivo.
| Cas No. | 1163-36-6 |
|---|---|
| Purity | ≥98% |
| Formula | C19H20ClN3 • HCl |
| Formula Wt. | 362.3 |
| IUPAC Name | 1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride (1:1) |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C4418 Info Sheet PDF |
|---|---|
| Brochures | TRP Channel Modulator Flyer |
Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.
Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.
Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.
Martínez-Mir MI, Estañ L, Morales-Olivas FJ, et al. Effect of histamine and histamine analogues on human isolated myometrial strips. Br J Pharmacol. 1992 Oct;107(2):528-31. PMID: 1358393.
