Description
Concanamycin A is an 18-membered macrolide lactone antibiotic produced by Streptomyces diastatochromogenes S45. Concanamycin A has shown fungicidal, larvicidal, and cytotoxic activities. In human oral squamous cell carcinoma cells, treatment with concanamycin A inhibited the acidification of vesicular organelles, inhibited proliferation, induced apoptosis, induced phosphorylation of p38, and increased the Bax/Bcl-2 ratio. Concanamycin A is known to be a specific inhibitor of vacuolar H+-ATPase.
References
Westley JW, Liu CM, Sello LH, et al. The structure and absolute configuration of the 18-membered macrolide lactone antibiotic X-4357B (concanamycin A). J Antibiot (Tokyo). 1984 Dec;37(12):1738-1740. PMID: 6526741
Kiyoshima T, Yoshida H, Wada H, et al. Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. PLoS One. 2013 Nov 20;8(11):e80998. PMID: 24278362
Yano K, Yanagisawa T, Mukae K, et al. Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8. Plant Signal Behav. 2015;10(11):e1082699. PMID: 26368310
