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商品详细LKT/COROSOLIC ACID/C5870/100 mg
LKT/COROSOLIC ACID/C5870/100 mg
LKT/COROSOLIC ACID/C5870/100 mg
商品编号: C5870-100mg
品牌: lktlabs
市场价: ¥17980.00
美元价: 10788.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Corosolic acid is a pentacyclic triterpene extracted from the leaves of Lagerstroemia speciosa. Corosolic acid exhibits antioxidative, anti-diabetic, anti-atherosclerotic, and anticancer activities in vitro and in vivo. This compound decreases blood sugar and increases glucose uptake in vivo, and decreases overall cholesterol levels potentially through inhibition of cholesterol acyltransferase. In lung adenocarcinoma cells, corosolic acid increases reactive oxygen species and induces caspase-mediated apoptosis; it also inhibits activation of STAT3, NF-kB activity, and MCP-1.

Product Info

Cas No.

4547-24-4

Purity

≥98%

Formula

C30H48O4

Formula Wt.

472.70

IUPAC Name

(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid

Synonym

2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C5870 MSDS PDF

Info Sheet

C5870 Info Sheet PDF

References

Nho KJ, Chun JM, Kim HK. Corosolic acid induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro. Food Chem Toxicol. 2013 Jun;56:8-17. PMID: 23454206.

Horlad H, Fujiwara Y, Takemura K, et al. Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells. Mol Nutr Food Res. 2013 Jun;57(6):1046-54. PMID: 23417831.

Miura T, Takagi S, Ishida T. Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid. Evid Based Complement Alternat Med. 2012;2012:871495. PMID: 23082086.

Chen H, Yang J, Zhang Q, et al. Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-κB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. Circ J. 2012;76(4):995-1003. PMID: 22293444.

Takagi S, Miura T, Ishihara E, et al. Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice. Biomed Res. 2010 Aug;31(4):213-8. PMID: 20834178.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂