Thioctic/lipoicacidisanendogenousorganosulfurthatexhibitsantioxidativeactivity.Thiscompoundiscommerciallyusedasadietarysupplementandcanbefoundinmeatandleafyvegetables.Thioctic/lipoicacidisrequiredforaerobicmetabolismandfunctionsasacofactorforthepyruvatedehydrogenasecomplex.Invitro,thiscompoundincreasesactivationofphaseIIenzymesandscavengesROSandRNS,protectingagainstoxidativestress.
| CasNo. | 1077-28-7 |
|---|---|
| Purity | ≥98% |
| Formula | C8H14O2S2 |
| FormulaWt. | 206.33 |
| ChemicalName | 1,2-Dithiolane-3-pentanoicacid |
| IUPACName | 5-(dithiolan-3-yl)pentanoicacid |
| Synonym | D,L-Thiocticacid |
| MeltingPoint | 60-62°C |
| Solubility | Insolubleinwater.Solubleinfatsolvents. |
| Appearance | Yellowcrystalpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L3561MSDSPDF |
|---|---|
| InfoSheet | L3561InfoSheetPDF |
ShayKP,MoreauRF,SmithEJ,etal.Alpha-lipoicacidasadietarysupplement:molecularmechanismsandtherapeuticpotential.BiochimBiophysActa.2009Oct;1790(10):1149-60.PMID:19664690.
PetersenShayK,MoreauRF,etal.Isalpha-lipoicacidascavengerofreactiveoxygenspeciesinvivo?Evidenceforitsinitiationofstresssignalingpathwaysthatpromoteendogenousantioxidantcapacity.IUBMBLife.2008Jun;60(6):362-7.PMID:18409172.
