Description
DihydromethysticinisakavalactoneoriginallyfoundinPipermethysticum(kavaplant)thatexhibitsantifungal,antiepileptic/anticonvulsant,neuroprotective,anticancer,andchemopreventiveactivities.ThiscompounddisplaysantimicrobialefficacyagainstspeciesofFusarium,Trichoderma,andColletotrichum.Dihydromethysticinalsobindsreceptorsite2andinhibitsvoltage-gatedNa+channels;itinhibitsL-typevoltage-gatedCa2+channelsaswell.Invivo,dihydromethysticininhibitstheformationofNNK-inducedtumorsand,separately,protectsagainstcerebralischemia-induceddamage.
References
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FrieseJ,GleitzJ.Kavain,dihydrokavain,anddihydromethysticinnon-competitivelyinhibitthespecificbindingof[3H]-batrachotoxinin-A20-alpha-benzoatetoreceptorsite2ofvoltage-gatedNa+channels.PlantaMed.1998Jun;64(5):458-9.PMID:9690349.
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