Description
SpinorphinisaheptapeptidewiththesequenceL-V-V-Y-P-W-T.Spinorphinisanendogenousenkephalinaseinhibitor,antagonizingenzymessuchasaminopeptidaseIV,neutralendopeptidase,dipeptidylpeptidaseIII(DPP3),andangiotensin-convertingenzyme(ACE);italsoactsasanantagoNISTattheP2X3receptor.Spinorphinexhibitsantinociceptive,antidepressant,gastrointestinalmotilitymodulating,anti-inflammatory,andimmunomodulatoryactivities.SpinorphinalsoactsasanantagonistatN-formylpeptidereceptors,preventingbindingofchemotacticf-MLFtoitsreceptoronpolymorphonuclear(PMN)neutrophilsandinhibitingneutrophilfunctionality.
References
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