SR1001isaninverseagoNISTatRORα/γreceptorsthatpreventsTh17celldevelopment,differentiation,andfunction.Itexhibitsanti-diabetic,anti-inflammatory,immunomodulatory,andantidepressantactivities.Inanimalmodelsofdiabetes,SR1001decreasesdiabetesincidenceandinsulitis,suppressesexpressionofpro-inflammatorycytokines,andincreaseslevelsofCD4+,Foxp3+Tregcells.Inanimalmodelsofdepression-likebehaviors,SR1001decreasesTh17-dependentlearnedhelplessness.
| CasNo. | 1335106-03-0 |
|---|---|
| Purity | ≥99% |
| Formula | C15H13F6N3O4S2 |
| FormulaWt. | 477.40 |
| IUPACName | N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide |
| Appearance | Tanpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S6800InfoSheetPDF |
|---|
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BeurelE,HarringtonLE,JopeRS.InflammatoryThelper17cellspromotedepression-likebehaviorinmice.BiolPsychiatry.2013Apr1;73(7):622-30.PMID:23174342.
SoltLA,KumarN,NuhantP,etal.SuppressionofTH17differentiationandautoimmunitybyasyntheticRORligand.Nature.2011Apr28;472(7344):491-4.PMID:21499262.
