Description
Stresscopin-relatedpeptideisa5-aminoacidextensionofurocortinIIthatincludesaprecedingH-P-G-S-Rtag.LikeurocortinII,stresscopin-relatedpeptideisamemberofthecorticotropin-releasingfactor(CRF)familythatbindstotheCRFtype2receptor(CRFR2).Stresscopin-relatedpeptidesignalingresultsinsuppressionoffoodintake,delayofgastricemptying,hypotension/hypertension(dependingonthemodel),andtachycardia.Stresscopin-relatedpeptideanditsanalogurocortinIImodulatestressresponsesandexhibitsanorexigenic,anxiogenic,anxiolytic,andgenerallypositiveinotropiceffects(suchasincreasesincoronarybloodblowandcardiacoutput)acrossawidevarietyofinvivomodels.
References
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