Description
Tyr-MIF-1isaneuromodulatorytetrapeptideoftheMIF-1familythatactsasanantagoNISTatμ-opioidreceptors(μORs),inhibitsopioid-inducedantinociceptionandanalgesiainvivo.Whenadministeredalone,Tyr-MIF-1mayexhibithistamine-dependentantinociceptiveactivityitself.Additionally,Tyr-MIF-1increasesgastricmotility,stimulatingantralandduodenalmyoelectricactivity.
References
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BochevaA,Dzambazova-MaximovaE.AntiopioidpropertiesoftheTYR-MIF-1family.MethodsFindExpClinPharmacol.2004Nov;26(9):673-7.PMID:15632952.
ZamfirovaR,BochevaA,TodorovS.InvolvementofH2-receptorsinthemechanismofanalgesicactionofTyr-MIF-1.ArchPhysiolBiochem.2003Dec;111(5):443-7.PMID:16026032.
MillionM,FioramontiJ,BuenoL.CentraladministrationofTyr-MIF-1stimulatesgastrointestinalmotilityinrats:evidencefortheinvolvementofdopamine,sigmaandCCKreceptors.Neuropeptides.1994Feb;26(2):77-85.PMID:7909585.