YangoninisadienolidekavalactoneoriginallyfoundinPipermethysticum(kavaplant).Yangoninexhibitsneuroprotective,neuromodulatory,andantifungalactivities.YangoninactivatescannABInoid(CB1)receptorsandpotentiatestheeffectsofGABA-Areceptors.Additionally,yangoninalsoactivatesNrf2inneuronsandastroglia,protectingagainstamyloid-β(Aβ)-inducedneurotoxicity.ThiscompounddisplaysantimicrobialefficacyagainstspeciesofFusarium,Trichoderma,andColletotrichum.
| CasNo. | 500-62-9 |
|---|---|
| Purity | ≥98% |
| Formula | C15H14O4 |
| FormulaWt. | 258.27 |
| ChemicalName | (E)-4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one |
| IUPACName | 4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one |
| Synonym | 4-Methoxy-6-(β-(p-anisyl)vinyl)-α-pyrone |
| MeltingPoint | 155-157°C |
| Solubility | Practicallyinsolubleinwater.Solubleinhotalcohol,ethylacetateandacetone.Slightlysolubleinbenzeneorether. |
| Appearance | Yellowish/GreenishCrystallinePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | Y0052MSDSPDF |
|---|---|
| InfoSheet | Y0052InfoSheetPDF |
LigrestiA,VillanoR,AllaràM,etal.Kavalactonesandtheendocannabinoidsystem:theplant-derivedyangoninisanovelCB1receptorligand.PharmacolRes.2012Aug;66(2):163-9.PMID:22525682.
WruckCJ,GötzME,HerdegenT,etal.Kavalactonesprotectneuralcellsagainstamyloidbetapeptide-inducedneurotoxicityviaextracellularsignal-regulatedkinase1/2-dependentnuclearfactorerythroid2-relatedfactor2activation.MolPharmacol.2008Jun;73(6):1785-95.PMID:18334601.
XuanTD,ElzaawelyAA,FukutaM,etal.HerbicidalandFungicidalActivitiesofLactonesinKava(Pipermethysticum).JAgricFoodChem.2006Feb8;54(3):720-5.PMID:16448174.
BoonenG,HäberleinH.InfluenceofgenuinekavapyroneenantiomersontheGABA-Abindingsite.PlantaMed.1998Aug;64(6):504-6.PMID:9776662.
