Description
ZLN005increasesexpressionofPPAR-γcoactivator-1α(PGC-1α),exhibitinganti-diabeticactivity.Inanimalmodelsofdiabetes,thiscompoundincreasesactivationofAMPK,stimulatesfatoxidation,andimprovesglucosetoleranceandinsulinsensitivity.
ZLN005increasesexpressionofPPAR-γcoactivator-1α(PGC-1α),exhibitinganti-diabeticactivity.Inanimalmodelsofdiabetes,thiscompoundincreasesactivationofAMPK,stimulatesfatoxidation,andimprovesglucosetoleranceandinsulinsensitivity.
CasNo. | 49671-76-3 |
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Purity | ≥98% |
Formula | C17H18N2 |
FormulaWt. | 250.35 |
IUPACName | 2-[4-(2-Methyl-2-propanyl)phenyl]-1H-benzimidazole |
StoreTemp | -20°C |
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ShipTemp | Ambient |
InfoSheet | Z4552InfoSheetPDF |
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ZhangLN,ZhouHY,FuYY,etal.Novelsmall-moleculePGC-1αtranscriptionalregulatorwithbeneficialeffectsondiabeticdb/dbmice.Diabetes.2013Apr;62(4):1297-307.PMID:23250358.