Description
Alsterpaulloneexhibitsanticancer,anti-angiogenic,antiviral,andneuroprotectiveactivities.Alsterpaulloneinhibitscyclin-dependentkinases(CDKs),inducingG2/Mphasecellcyclearrestandapoptosisinleukemiacells.Additionally,alsterpaulloneinhibitsglycogensynthasekinase3(GSK-3),inducingWntsignaling;inticks,thisresultsinanti-fertilitypotential,decreasingegghatchingactivity.AlsterpaullonealsoinhibitsHIV-1replicationandproliferation.InexvivomodelsofAlzheimer’sdisease,thiscompoundprotectsagainstneuronaldeathanddecreasesphosphorylationoftauprotein.
References
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