LKT/AMOXAPINE/A5059/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/AMOXAPINE/A5059/250 mg

LKT/AMOXAPINE/A5059/250 mg

商品编号： A5059-250mg

品牌： lktlabs

市场价： ¥1800.00

美元价： 1080.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID A5059

Cas No. 14028-44-5

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Amoxapine is a tricyclic antidepressant that acts as an antagonist at 5-HT2/3/6/7 receptors, D2/3/4 receptors, H1 histamine receptors, α1-adrenergic receptors, and also on the serotonin transporter (SERT) and norepinephrine transporter (NET). Amoxapine also acts as an antagonist at hERG K+ channels, potentially prolonging the cardiac QT interval. Amoxapine exhibits antidepressant, antipsychotic, and antibacterial activities. Amoxapine inhibits GABA- and NMDA-induced increases in intracellular Ca2+ levels and increases leu-enkephalin levels in vivo. This compound exhibits antibiotic activity through inhibition of bacterial β-glucuronidase.

Product Info

Cas No.	14028-44-5
Purity	≥98%
Formula	C₁₇H₁₆ClN₃O
Formula Wt.	313.78
Chemical Name	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
IUPAC Name	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
Melting Point	175.5C
Appearance	Yellow crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	A5059 MSDS PDF
Info Sheet	A5059 Info Sheet PDF

References

Ahmad S, Hughes MA, Yeh LA, et al. Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors. J Biomol Screen. 2012 Aug;17(7):957-65. PMID: 22535688.

Yang G, Zhou MH, Ren Z, et al. Amoxapine inhibits delayed outward rectifier K(+) currents in cerebellar granule cells via dopamine receptor and protein kinase A activation. Cell Physiol Biochem. 2011;28(1):163-74. PMID: 21865859.

Obers S, Staudacher I, Ficker E, et al. Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. PMID: 20229012.

Chaudhry IB, Husain N, Khan S, et al. Amoxapine as an antipsychotic: comparative study versus haloperidol. J Clin Psychopharmacol. 2007 Dec;27(6):575-81. PMID: 18004123.

Takebayashi M, Kagaya A, Inagaki M, et al. Effects of antidepressants on gamma-aminobutyric acid- and N-methyl-D-aspartate-induced intracellular Ca(2+) concentration increases in primary cultured rat cortical neurons. Neuropsychobiology. 2000;42(3):120-6. PMID: 11015029.

Roth BL, Craigo SC, Choudhary MS, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. PMID: 7908055.

Gozlan H, Saddiki-Traki F, Merahi N, et al. Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats. Encephale. 1991 Dec;17 Spec No 3:415-22. PMID: 1666997.

Hamon M, Gozlan H, Bourgoin S, et al. Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology. 1987 Jun;26(6):531-9. PMID: 3037421.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂