LKT/AMOXAPINE/A5059/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/AMOXAPINE/A5059/5 g

LKT/AMOXAPINE/A5059/5 g

商品编号： A5059-5g

品牌： lktlabs

市场价： ¥9720.00

美元价： 5832.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDA5059

CasNo.14028-44-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

AmoxapineisatricyclicantidepressantthatactsasanantagoNISTat5-HT2/3/6/7receptors,D2/3/4receptors,H1histaminereceptors,α1-adrenergicreceptors,andalsoontheSEROtonintransporter(SERT)andnorepinephrinetransporter(NET).AmoxapinealsoactsasanantagonistathERGK+channels,potentiallyprolongingthecardiacQTinterval.Amoxapineexhibitsantidepressant,antipsychotic,andantibacterialactivities.AmoxapineinhibitsGABA-andNMDA-inducedincreasesinintracellularCa2+levelsandincreasesleu-enkephalinlevelsinvivo.Thiscompoundexhibitsantibioticactivitythroughinhibitionofbacterialβ-glucuronidase.

ProductInfo

CasNo.	14028-44-5
Purity	≥98%
Formula	C₁₇H₁₆ClN₃O
FormulaWt.	313.78
ChemicalName	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
IUPACName	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
MeltingPoint	175.5C
Appearance	Yellowcrystallinepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	A5059MSDSPDF
InfoSheet	A5059InfoSheetPDF

References

AhmadS,HughesMA,YehLA,etal.Potentialrepurposingofknowndrugsaspotentbacterialβ-glucuronidaseinhibitors.JBiomolScreen.2012Aug;17(7):957-65.PMID:22535688.

YangG,ZhouMH,RenZ,etal.AmoxapineinhibitsdelayedoutwardrectifierK(+)currentsincerebellargranulecellsviadopaminereceptorandproteinkinaseAactivation.CellPhysiolBiochem.2011;28(1):163-74.PMID:21865859.

ObersS,StaudacherI,FickerE,etal.MultiplemechanismsofhERGliABIlity:K+currentinhibition,disruptionofproteintrafficking,andapoptosisinducedbyamoxapine.NaunynSchmiedebergsArchPharmacol.2010May;381(5):385-400.PMID:20229012.

ChaudhryIB,HusainN,KhanS,etal.Amoxapineasanantipsychotic:comparativestudyversushaloperidol.JClinPsychopharmacol.2007Dec;27(6):575-81.PMID:18004123.

TakebayashiM,KagayaA,InagakiM,etal.Effectsofantidepressantsongamma-aminobutyricacid-andN-methyl-D-aspartate-inducedintracellularCa(2+)concentrationincreasesinprimaryculturedratcorticalneurons.NeuropsychoBIOLOGy.2000;42(3):120-6.PMID:11015029.

RothBL,CraigoSC,ChoudharyMS,etal.Bindingoftypicalandatypicalantipsychoticagentsto5-hydroxytryptamine-6and5-hydroxytryptamine-7receptors.JPharmacolExpTher.1994Mar;268(3):1403-10.PMID:7908055.

GozlanH,Saddiki-TrakiF,MerahiN,etal.Preclinicalpharmacologyofamoxapineandamitriptyline.Implicationsofserotoninergicandopiodergicsystemsintheircentraleffectinrats.Encephale.1991Dec;17SpecNo3:415-22.PMID:1666997.

HamonM,GozlanH,BourgoinS,etal.OpioidreceptorsandneuropeptidesintheCNSinratstreatedchronicallywithamoxapineoramitriptyline.Neuropharmacology.1987Jun;26(6):531-9.PMID:3037421.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂